Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918
Identifieur interne : 001239 ( Main/Exploration ); précédent : 001238; suivant : 001240Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918
Auteurs : Martha I. Nelson [États-Unis] ; Cécile Viboud [États-Unis] ; Lone Simonsen [États-Unis] ; Ryan T. Bennett [États-Unis] ; Sara B. Griesemer [États-Unis] ; Kirsten St. George [États-Unis] ; Jill Taylor [États-Unis] ; David J. Spiro [États-Unis] ; Naomi A. Sengamalay [États-Unis] ; Elodie Ghedin [États-Unis] ; Jeffery K. Taubenberger [États-Unis] ; Edward C. Holmes [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2008.
Abstract
The H1N1 subtype of influenza A virus has caused substantial morbidity and mortality in humans, first documented in the global pandemic of 1918 and continuing to the present day. Despite this disease burden, the evolutionary history of the A/H1N1 virus is not well understood, particularly whether there is a virological basis for several notable epidemics of unusual severity in the 1940s and 1950s. Using a data set of 71 representative complete genome sequences sampled between 1918 and 2006, we show that segmental reassortment has played an important role in the genomic evolution of A/H1N1 since 1918. Specifically, we demonstrate that an A/H1N1 isolate from the 1947 epidemic acquired novel PB2 and HA genes through intra-subtype reassortment, which may explain the abrupt antigenic evolution of this virus. Similarly, the 1951 influenza epidemic may also have been associated with reassortant A/H1N1 viruses. Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized.
Url:
DOI: 10.1371/journal.ppat.1000012
PubMed: 18463694
PubMed Central: 2262849
Affiliations:
- États-Unis
- Maryland, Pennsylvanie, État de New York
- Pittsburgh, University Park (Pennsylvanie)
- Université d'État de Pennsylvanie, Université de Pittsburgh
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Sengamalay</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ghedin, Elodie" sort="Ghedin, Elodie" uniqKey="Ghedin E" first="Elodie" last="Ghedin">Elodie Ghedin</name><affiliation wicri:level="4"><nlm:aff id="aff7"><addr-line>Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fogarty International Center, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The H1N1 subtype of influenza A virus has caused substantial morbidity and mortality in humans, first documented in the global pandemic of 1918 and continuing to the present day. Despite this disease burden, the evolutionary history of the A/H1N1 virus is not well understood, particularly whether there is a virological basis for several notable epidemics of unusual severity in the 1940s and 1950s. Using a data set of 71 representative complete genome sequences sampled between 1918 and 2006, we show that segmental reassortment has played an important role in the genomic evolution of A/H1N1 since 1918. Specifically, we demonstrate that an A/H1N1 isolate from the 1947 epidemic acquired novel PB2 and HA genes through intra-subtype reassortment, which may explain the abrupt antigenic evolution of this virus. Similarly, the 1951 influenza epidemic may also have been associated with reassortant A/H1N1 viruses. Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Johnson, Np" uniqKey="Johnson N">NP Johnson</name></author><author><name sortKey="Mueller, J" uniqKey="Mueller J">J Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Logan, Wp" uniqKey="Logan W">WP Logan</name></author><author><name sortKey="Mackay, Dg" uniqKey="Mackay D">DG 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Simonsen</name></author><author><name sortKey="Clarke, Ml" uniqKey="Clarke M">ML Clarke</name></author><author><name sortKey="Schonberger, Lb" uniqKey="Schonberger L">LB Schonberger</name></author><author><name sortKey="Arden, Nh" uniqKey="Arden N">NH Arden</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Jf" uniqKey="Young J">JF Young</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Rocha, Ep" 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uniqKey="Galvani A">AP Galvani</name></author><author><name sortKey="Bush, Rm" uniqKey="Bush R">RM Bush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakajima, K" uniqKey="Nakajima K">K Nakajima</name></author><author><name sortKey="Desselberger, U" uniqKey="Desselberger U">U Desselberger</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oxford, Js" uniqKey="Oxford J">JS Oxford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakajima, S" uniqKey="Nakajima S">S Nakajima</name></author><author><name sortKey="Nishikawa, F" uniqKey="Nishikawa F">F Nishikawa</name></author><author><name sortKey="Nakajima, K" uniqKey="Nakajima K">K Nakajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name></author><author><name sortKey="Simonsen, 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sortKey="Posada, D" uniqKey="Posada D">D Posada</name></author><author><name sortKey="Crandall, Ka" uniqKey="Crandall K">KA Crandall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maddison, Dr" uniqKey="Maddison D">DR Maddison</name></author><author><name sortKey="Maddison, Wp" uniqKey="Maddison W">WP Maddison</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Pittsburgh</li><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université d'État de Pennsylvanie</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name></region><name sortKey="Bennett, Ryan T" sort="Bennett, Ryan T" uniqKey="Bennett R" first="Ryan T." last="Bennett">Ryan T. Bennett</name><name sortKey="Ghedin, Elodie" sort="Ghedin, Elodie" uniqKey="Ghedin E" first="Elodie" last="Ghedin">Elodie Ghedin</name><name sortKey="Griesemer, Sara B" sort="Griesemer, Sara B" uniqKey="Griesemer S" first="Sara B." last="Griesemer">Sara B. Griesemer</name><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><name sortKey="Sengamalay, Naomi A" sort="Sengamalay, Naomi A" uniqKey="Sengamalay N" first="Naomi A." last="Sengamalay">Naomi A. Sengamalay</name><name sortKey="Simonsen, Lone" sort="Simonsen, Lone" uniqKey="Simonsen L" first="Lone" last="Simonsen">Lone Simonsen</name><name sortKey="Spiro, David J" sort="Spiro, David J" uniqKey="Spiro D" first="David J." last="Spiro">David J. Spiro</name><name sortKey="St George, Kirsten" sort="St George, Kirsten" uniqKey="St George K" first="Kirsten" last="St. George">Kirsten St. George</name><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><name sortKey="Taylor, Jill" sort="Taylor, Jill" uniqKey="Taylor J" first="Jill" last="Taylor">Jill Taylor</name><name sortKey="Viboud, Cecile" sort="Viboud, Cecile" uniqKey="Viboud C" first="Cécile" last="Viboud">Cécile Viboud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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